ON MODELING THE POPULATION DISTRIBUTION OF HEAMOPHILLIA USING GENE SEQUENCING DATA.

Title of Publication: ON MODELING THE POPULATION DISTRIBUTION OF HEAMOPHILLIA USING GENE SEQUENCING DATA.
Author(s): ALIH EKELE, SULEIMAN S.A
Year of Publication: 2012

ABSTRACT
The distribution of heamophillia disease as one of the x-linked trait was modeled using a genome sequencing data of 9731 individuals from Canadian Haemophillia registry. The model was initiated from the Hardy-Weinberg’s law which invokes the binomial expansion for its verification. The model for estimating gene proportion with haemophillia was obtained and applied to the genome sequencing data over n=20 filial generations. The result obtained indicated a stable distribution of heamophillia among males and females at the 13th–filial generation (F13). The tau-statistic indicated an almost perfect relationship between the heamophilliac males and females (|τ|=0.974)). The regression model of hm = 1.22 – 2.00 hf was fitted to the data with an R2–value of 99.7%. The goodness of fit test revealed a zero deviation of the estimates of the model from the actual value at 5% level of significance.
Keywords: tau-statistic, filial generation, level of significance, R2–value.


NSA Executives

President :: Prof. S.I. Onyeagu
1st Vice President :: Dr. G.U. Ebuh
2nd Vice President :: Dr. O.E. Olubusoye
National Secretary :: Mr. O.T. Arowolo
Assistant National Secretary :: Mr. C. O. Aronu
National Financial Secretary :: Mr. R.O. Olaitan
National Treasurer :: Mrs. F.O. Obikudu
Business Manager :: Mr. B.F. Ajibade
Editor-in-chief :: Prof. J.I. Mbegbu
Ordinary Council Member 1 :: Elder E. E. Umanah
Ordinary Council Member 2 :: Prof. S. U. Gulumbe
Immediate Past President :: Dr. M.M. Tumala
Editorial Team

Admin

Feed Back
We will love to hear from you

Planners, Demographers, Analysts and Corporate Organisations with interest in Statistics.

You must be logged in to use our feedback system



Publish with Us

The Nigerian Statistical Association was founded in 1976 as a non-profit making professional body of Statisticians, Economists.

Feel free to drop us a note
Unsplashed background img 3
Send us a message