Title of Publication: ON MODELING THE POPULATION DISTRIBUTION OF HEAMOPHILLIA USING GENE SEQUENCING DATA.
Author(s): ALIH EKELE, SULEIMAN S.A
Year of Publication: 2012
The distribution of heamophillia disease as one of the x-linked trait was modeled using a genome sequencing data of 9731 individuals from Canadian Haemophillia registry. The model was initiated from the Hardy-Weinberg’s law which invokes the binomial expansion for its verification. The model for estimating gene proportion with haemophillia was obtained and applied to the genome sequencing data over n=20 filial generations. The result obtained indicated a stable distribution of heamophillia among males and females at the 13th–filial generation (F13). The tau-statistic indicated an almost perfect relationship between the heamophilliac males and females (|τ|=0.974)). The regression model of hm = 1.22 – 2.00 hf was fitted to the data with an R2–value of 99.7%. The goodness of fit test revealed a zero deviation of the estimates of the model from the actual value at 5% level of significance.
Keywords: tau-statistic, filial generation, level of significance, R2–value.